Research pipeline — Atlas sheet 03
From feedstock to application, in six stages.
Each stage is a checkpoint with defined evidence, metrics and deliverables. Use the explorer below to move through the pipeline — stage panels update in place, without leaving the page.
Pipeline explorer
Select a stage.
Evidence notes, key metrics, related publications and live programme status update for each stage — no navigation required.
01 · Feedstock
Programme status: 2 activeEvidence notes
- Fourteen production strains grow on mixed agricultural-residue hydrolysates without sugar supplementation.
- Acetate tolerance above 12 g/L maintained across three consecutive passages.
- Recovered CO₂ is co-fed as a carbon source via methanol assimilation pathways.
Related publications
Preprint · 2024
Recovered CO₂ as a co-substrate for methanol-based fermentation
White paper · 2025
Meridian Platform Report 2025: precision fermentation for material feedstocks
Key metrics
14Strains on hydrolysate
6Carbon sources
>12 g/LAcetate tolerance
100%Non-food feedstocks
Live programmes
CO₂ assimilation pathways
Hydrolysate adaptation programme
02 · Organism design
Programme status: 1 activeEvidence notes
- Genome-scale metabolic models predict pathway carbon yield within 6% of measured titre across 40 engineered variants.
- Automated strain construction reduces manual bench time by roughly 70% per design cycle.
- Design–build–test–learn cycle currently runs 21–28 days per target.
Related publications
Peer-reviewed · 2024
Genome-scale model-guided engineering of isobutanol production in Pichia pastoris
Peer-reviewed · 2023
Continuous culture stabilisation of high-titre protein secretion
Key metrics
21–28 dDBTL cycle
40Variants modelled
6%Model-to-measure drift
14Strains in collection
Live programmes
Strain design automation
03 · Fermentation
Programme status: 1 scalingEvidence notes
- Continuous culture holds product titre within ±8% of setpoint over 30-day runs at 200 L.
- Defined, animal-free media reduce batch-to-batch variance in raw-material sourcing.
- On-line biomass and substrate sensors feed the published process dataset.
Related publications
Peer-reviewed · 2023
Continuous culture stabilisation of high-titre protein secretion
Peer-reviewed · 2024
Tolerance of engineered Saccharomyces cerevisiae to acetate-rich lignocellulosic hydrolysates
Key metrics
2,000 LPilot scale
30 dContinuous run
±8%Titre stability
0Animal-derived media
Live programmes
Continuous culture programme
04 · Purification
Programme status: 1 activeEvidence notes
- Membrane train recovers the target polymer at pilot scale with a reconciled mass balance to the gram.
- Chromatographic polishing reaches the purity required for film-grade material specifications.
- Drying and conditioning preserve molecular weight within specification tolerance.
Related publications
Peer-reviewed · 2023
Membrane-based purification of extracellular polymers at pilot scale
Key metrics
92%Recovery yield
<1%Mass-balance gap
3Unit operations
CoARelease per lot
Live programmes
Downstream recovery train
05 · Validation
Programme status: 1 activeEvidence notes
- Material validation runs twelve assay methods covering composition, thermal behaviour, mechanical properties and purity.
- Film and fibre trials at lab scale reproduce extrusion behaviour batch over batch.
- Application test reports are published alongside each validated material grade.
Related publications
Conference · 2025
Application testing of fermented elastomer precursors in film extrusion
Key metrics
12Assay methods
3Material grades
2Application tracks
100%Lots with CoA
Live programmes
Material validation suite
06 · Application
Programme status: 1 pausedEvidence notes
- Application scaling requires partner conversion lines; the current programme is paused pending partner alignment.
- Lab-scale film extrusion confirms processability of fermentation-derived polymer grades.
- Market roadmap prioritises fibre, film and elastomer segments with defined specification sheets.
Related publications
Conference · 2025
Application testing of fermented elastomer precursors in film extrusion
Key metrics
3Target segments
2Partner discussions
LabExtrusion scale
PausedProgramme status
Live programmes
Film application scaling
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Programme owners publish updates each quarter. Research partners and responsible investors can align to specific stages under defined governance.